Patients gradually titrate their dose (number of sprays per day) during the first two weeks of treatment.1

On day 1 patients take one spray of Sativex in the evening (between 4pm and bedtime). They then gradually increase their dose following the pattern given in the table below until they reach a dose that provides optimum symptom relief.1

Dose titration schedule for Sativex1
DayNumber of sprays in the morning (between waking and midday)Number of sprays in the evening (between 4pm and bedtime)(Total number of sprays per day)
1011
2011
3022
4022
5123
6134
7145
8246
9257
10358
11369
124610
134711
145712

Once they have titrated their dose to achieve optimum symptom relief, patients can adjust their dose according to how they are feeling on a day-to-day basis, and over time as their disease progresses.

Maximum recommended dose

Patients may increase their dose up to a maximum of 12 sprays per day if needed.1 This information is also included in the Patient Information Leaflet and the patient booklet.

In routine clinical practice, the median number of daily sprays is 4.2 In clinical trials, the median number of daily sprays used by MS patients was 8.1

Patients should leave at least 15 minutes between two successive sprays.

Review by a specialist

The patient’s response to Sativex is reviewed by the specialist physician after four weeks of treatment. If a clinically significant improvement in spasticity-related symptoms is not seen during this initial trial of therapy, treatment should be stopped. The value of long-term treatment should also be re-evaluated periodically.1

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